AustralieFrV1, Main, Exploration, bibRecord, 002621

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

Identifieur interne : 002621 ( Main/Exploration ); précédent : 002620; suivant : 002622

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

Auteurs : Ai-Hua Jin [Australie] ; Mathilde R. Israel [Australie] ; Marco C. Inserra [Australie] ; Jennifer J. Smith [Australie] ; Richard J. Lewis [Australie] ; Paul F. Alewood [Australie] ; Irina Vetter [Australie] ; Sébastien Dutertre [Australie, France]

Source :

Proceedings of the Royal Society B: Biological Sciences [ 0962-8452 ] ; 2015.

RBID : PMC:4528551

Descripteurs français

KwdFr :
- Alignement de séquences, Animaux, Comportement prédateur, Conotoxines (génétique), Conotoxines (métabolisme), Conotoxines (pharmacologie), Conus (génétique), Conus (physiologie), Douleur, Mâle, Souris (physiologie), Souris de lignée C57BL, Séquence d'acides aminés, Évolution biologique.
MESH :
- génétique : Conotoxines, Conus.
- métabolisme : Conotoxines.
- pharmacologie : Conotoxines.
- physiologie : Conus, Souris.
- Alignement de séquences, Animaux, Comportement prédateur, Douleur, Mâle, Souris de lignée C57BL, Séquence d'acides aminés, Évolution biologique.

English descriptors

KwdEn :
- Amino Acid Sequence, Animals, Biological Evolution, Conotoxins (genetics), Conotoxins (metabolism), Conotoxins (pharmacology), Conus Snail (genetics), Conus Snail (physiology), Male, Mice (physiology), Mice, Inbred C57BL, Pain, Predatory Behavior, Sequence Alignment.
MESH :
- chemical , genetics : Conotoxins.
- chemical , metabolism : Conotoxins.
- chemical , pharmacology : Conotoxins.
- genetics : Conus Snail.
- physiology : Conus Snail, Mice.
- Amino Acid Sequence, Animals, Biological Evolution, Male, Mice, Inbred C57BL, Pain, Predatory Behavior, Sequence Alignment.

Abstract

Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target K_v and Na_v channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Na_v channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (Conus suturatus). SuVIA is equipotent at hNa_V1.3, hNa_V1.4 and hNa_V1.6 with EC₅₀s in the low nanomolar range. SuVIA also increased peak hNa_V1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from –15 mV to –25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that δ-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that δ-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528551

DOI: 10.1098/rspb.2015.0817
PubMed: 26156767
PubMed Central: 4528551

Affiliations:

Australie, France

Le document en format XML

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<term>Conotoxins (metabolism)</term>
<term>Conotoxins (pharmacology)</term>
<term>Conus Snail (genetics)</term>
<term>Conus Snail (physiology)</term>
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<term>Comportement prédateur</term>
<term>Conotoxines (génétique)</term>
<term>Conotoxines (métabolisme)</term>
<term>Conotoxines (pharmacologie)</term>
<term>Conus (génétique)</term>
<term>Conus (physiologie)</term>
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<front><div type="abstract" xml:lang="en"><p>Some venomous cone snails feed on small fishes using an immobilizing combination of synergistic venom peptides that target K<sub>v</sub>
 and Na<sub>v</sub>
 channels. As part of this envenomation strategy, δ-conotoxins are potent ichtyotoxins that enhance Na<sub>v</sub>
 channel function. δ-Conotoxins belong to an ancient and widely distributed gene superfamily, but any evolutionary link from ancestral worm-eating cone snails to modern piscivorous species has not been elucidated. Here, we report the discovery of SuVIA, a potent vertebrate-active δ-conotoxin characterized from a vermivorous cone snail (<italic>Conus suturatus</italic>
). SuVIA is equipotent at hNa<sub>V</sub>
1.3, hNa<sub>V</sub>
1.4 and hNa<sub>V</sub>
1.6 with EC<sub>50</sub>
s in the low nanomolar range. SuVIA also increased peak hNa<sub>V</sub>
1.7 current by approximately 75% and shifted the voltage-dependence of activation to more hyperpolarized potentials from –15 mV to –25 mV, with little effect on the voltage-dependence of inactivation. Interestingly, the proximal venom gland expression and pain-inducing effect of SuVIA in mammals suggest that δ-conotoxins in vermivorous cone snails play a defensive role against higher order vertebrates. We propose that δ-conotoxins originally evolved in ancestral vermivorous cones to defend against larger predators including fishes have been repurposed to facilitate a shift to piscivorous behaviour, suggesting an unexpected underlying mechanism for this remarkable evolutionary transition.</p>
</div>
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<tree><country name="Australie"><noRegion><name sortKey="Jin, Ai Hua" sort="Jin, Ai Hua" uniqKey="Jin A" first="Ai-Hua" last="Jin">Ai-Hua Jin</name>
</noRegion>
<name sortKey="Alewood, Paul F" sort="Alewood, Paul F" uniqKey="Alewood P" first="Paul F." last="Alewood">Paul F. Alewood</name>
<name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
<name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
<name sortKey="Inserra, Marco C" sort="Inserra, Marco C" uniqKey="Inserra M" first="Marco C." last="Inserra">Marco C. Inserra</name>
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<name sortKey="Lewis, Richard J" sort="Lewis, Richard J" uniqKey="Lewis R" first="Richard J." last="Lewis">Richard J. Lewis</name>
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<name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
<name sortKey="Vetter, Irina" sort="Vetter, Irina" uniqKey="Vetter I" first="Irina" last="Vetter">Irina Vetter</name>
</country>
<country name="France"><noRegion><name sortKey="Dutertre, Sebastien" sort="Dutertre, Sebastien" uniqKey="Dutertre S" first="Sébastien" last="Dutertre">Sébastien Dutertre</name>
</noRegion>
</country>
</tree>
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   |texte=   δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails
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Serveur d'exploration sur les relations entre la France et l'Australie

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

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	Serveur d'exploration sur les relations entre la France et l'Australie
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